Early emergence of ganciclovir-resistant human cytomegalovirus strains in children with primary combined immunodeficiency.

  title={Early emergence of ganciclovir-resistant human cytomegalovirus strains in children with primary combined immunodeficiency.},
  author={Dana G. Wolf and Issac Yaniv and Alik Honigman and Imad Kassis and Tomy Schonfeld and Shai Ashkenazi},
  journal={The Journal of infectious diseases},
  volume={178 2},
Children with primary combined immunodeficiency (CID) and human cytomegalovirus (HCMV) infection often deteriorate despite antiviral therapy. In this study, the emergence of ganciclovir-resistant strains was examined in 6 children with CID and HCMV infection, using sequence analysis of the HCMV UL97 gene and virus susceptibility assays. Mutations in the proposed ATP binding site associated with ganciclovir resistance were found in 4 of the 6 children. In 1 patient with B severe CID, an unusual… CONTINUE READING

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