Early embryonic lethality caused by targeted disruption of the mouse selenocysteine tRNA gene (Trsp).

@article{Bsl1997EarlyEL,
  title={Early embryonic lethality caused by targeted disruption of the mouse selenocysteine tRNA gene (Trsp).},
  author={Michael R. B{\"o}sl and Kazuaki Takaku and Masamichi Oshima and Shin-Ichiro Nishimura and Makoto Mark Taketo},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 11},
  pages={5531-4}
}
Selenoprotein biosynthesis is mediated by tRNASec, which inserts selenocysteine at UGA codons in a complex, context-specific manner. This opal suppressor serves in the conversion of serine to selenocysteine as well. The mouse tRNASec gene (Trsp) maps to a proximal segment of chromosome 7. We constructed mice carrying a targeted deletion of the Trsp gene. The heterozygous mutants were viable, fertile, and appeared normal. Although the level of tRNASec was reduced to about 50%-80% of the wild… CONTINUE READING
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