Early embryonic death-associated changes in genome-wide gene expression profiles in the fetal placenta of the cow carrying somatic nuclear-derived cloned embryo.

@article{Oishi2006EarlyED,
  title={Early embryonic death-associated changes in genome-wide gene expression profiles in the fetal placenta of the cow carrying somatic nuclear-derived cloned embryo.},
  author={Masahito Oishi and Hiroshi Gohma and Kazuiyoshi Hashizume and Yukio Taniguchi and Hiroshi Yasue and Seiya Takahashi and Takahisa Yamada and Yoshiyuki Sasaki},
  journal={Molecular reproduction and development},
  year={2006},
  volume={73 4},
  pages={404-9}
}
Successful somatic nuclear transfer-derived cloning has been reported in cattle; however, the cloned embryo is highly susceptible to death around day 60 of gestation leading to early embryonic loss. The early embryonic death is postulated to possibly arise in part from an atypical placentation. We have performed cDNA macroarray analysis using 3,353 of the previously cataloged 4,165 genes, in order to characterize the early embryonic death-associated changes in genome-wide gene expression… CONTINUE READING

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