Early effects of tumour necrosis factor alpha blockade on skin and synovial tissue in patients with active psoriasis and psoriatic arthritis.

@article{Goedkoop2004EarlyEO,
  title={Early effects of tumour necrosis factor alpha blockade on skin and synovial tissue in patients with active psoriasis and psoriatic arthritis.},
  author={Amber Y. Goedkoop and Maarten C. Kraan and Marcel B. M. Teunissen and Daisy I. Picavet and Menno A. de Rie and Jan Dositheus Bos and Paul Peter Tak},
  journal={Annals of the rheumatic diseases},
  year={2004},
  volume={63 7},
  pages={769-73}
}
BACKGROUND Tumour necrosis factor alpha (TNFalpha) blockade using infliximab, a chimeric anti-TNFalpha antibody, is an effective treatment for both psoriasis and psoriatic arthritis (PsA). OBJECTIVE To analyse the early effects of infliximab treatment on serial skin and synovial tissue biopsy samples. METHODS Twelve patients with both active psoriasis and PsA received a single infusion of either infliximab (3 mg/kg) (n = 6) or placebo (n = 6) intravenously. Synovial tissue and lesional skin… CONTINUE READING