Early effects of tocilizumab on bone and bone marrow lesions in a collagen-induced arthritis monkey model.

@article{Kato2008EarlyEO,
  title={Early effects of tocilizumab on bone and bone marrow lesions in a collagen-induced arthritis monkey model.},
  author={Atsuhiko Kato and Saori Matsuo and Hirotake Takai and Yasushi Uchiyama and Masahiko Mihara and Masami Suzuki},
  journal={Experimental and molecular pathology},
  year={2008},
  volume={84 3},
  pages={262-70}
}
To understand the contribution of IL-6/IL-6R to subchondral bone and bone marrow abnormality in RA patients and the effects of tocilizumab on those abnormalities, we evaluated early change in a collagen-induced arthritis (CIA) monkey model with or without a single administration of tocilizumab. Six CIA cynomolgus monkeys received tocilizumab and 3 CIA monkeys received vehicle only. Their interphalangeal joints were analyzed using HE, silver impregnation (SI), or immunohistochemistry (RANKL… CONTINUE READING

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Tocilizumab treatment recovered changes in the CIA monkeys as a result of the co - differentiation between the osteoclasts and the osteoblast / stramal cells , at least partially through the suppression of RANKL overproduction .
Tocilizumab treatment recovered changes in the CIA monkeys as a result of the co - differentiation between the osteoclasts and the osteoblast / stramal cells , at least partially through the suppression of RANKL overproduction .
Tocilizumab treatment recovered changes in the CIA monkeys as a result of the co - differentiation between the osteoclasts and the osteoblast / stramal cells , at least partially through the suppression of RANKL overproduction .
OsteoblastsSibling in is aOsteoclasts
Tocilizumab treatment recovered changes in the CIA monkeys as a result of the co - differentiation between the osteoclasts and the osteoblast / stramal cells , at least partially through the suppression of RANKL overproduction .
OsteoclastsSibling in is aOsteoblasts
Tocilizumab treatment recovered changes in the CIA monkeys as a result of the co - differentiation between the osteoclasts and the osteoblast / stramal cells , at least partially through the suppression of RANKL overproduction .
Tocilizumab treatment recovered changes in the CIA monkeys as a result of the co - differentiation between the osteoclasts and the osteoblast / stramal cells , at least partially through the suppression of RANKL overproduction .
Their interphalangeal joints were analyzed using HE , silver impregnation ( SI ) , or immunohistochemistry ( RANKL ) staining .
Their interphalangeal joints were analyzed using HE , silver impregnation ( SI ) , or immunohistochemistry ( RANKL ) staining .
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