Early effects of raloxifene on clinical vertebral fractures at 12 months in postmenopausal women with osteoporosis.

  title={Early effects of raloxifene on clinical vertebral fractures at 12 months in postmenopausal women with osteoporosis.},
  author={Michael J Maricic and Jonathan D Adachi and Somnath Sarkar and Wentao Wu and M Wong and Kristine D. Harper},
  journal={Archives of internal medicine},
  volume={162 10},
BACKGROUND Raloxifene hydrochloride therapy reduces the risk for vertebral fractures at 3 years, but the effects on clinical vertebral fractures in the first year are not known. METHODS The Multiple Outcomes of Raloxifene Evaluation (MORE) Trial enrolled 7705 women with osteoporosis, defined by prevalent vertebral fractures and/or a bone mineral density (BMD) T score at or below -2.5, who were treated with placebo or raloxifene at a dosage of 60 or 120 mg/d for 3 years. New clinical vertebral… CONTINUE READING


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