Early effects of lafutidine or rabeprazole on intragastric acidity: which drug is more suitable for on-demand use?

@article{Inamori2005EarlyEO,
  title={Early effects of lafutidine or rabeprazole on intragastric acidity: which drug is more suitable for on-demand use?},
  author={Masahiko Inamori and Jun-ichi Togawa and Tomoyuki Iwasaki and Yutaka Ozawa and Taisuke Kikuchi and Kenichi Muramatsu and Gaku Chiguchi and Shuhei Matsumoto and Harunobu Kawamura and Yasunobu Abe and Hiroyuki Kirikoshi and Noritoshi Kobayashi and Takeshi Shimamura and Kensuke Kubota and Takashi Sakaguchi and Satoru Saito and Norio Ueno and Atsushi Nakajima},
  journal={Journal of Gastroenterology},
  year={2005},
  volume={40},
  pages={453-458}
}
Medication for the relief of heartburn should have the rapid onset of action required for on-demand use. We studied the inhibition of gastric acid secretion by lafutidine and rabeprazole, given in single doses to fasting and postprandial subjects. A total of 22 healthy male, Helicobacter pylori-negative volunteers participated in this randomized, two-way crossover study. They were randomly assigned to receive a single oral dose of 10 mg lafutidine or 20 mg rabeprazole after fasting overnight… CONTINUE READING
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Lafutidine, a novel histamine H2 receptor antagonist, inhibits daytime acid secretion in both H. pylori infected and non-infected human subjects (abstract)

  • T Saitoh, Y Fukushima, H Otsuka, J Hirakawa, M Ishikawa, N Takahashi
  • J Gastroenterol Hepatol
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