Early effects of acid-base management during hypothermia on cerebral infarct volume, edema, and cerebral blood flow in acute focal cerebral ischemia in rats.

@article{Kollmar2002EarlyEO,
  title={Early effects of acid-base management during hypothermia on cerebral infarct volume, edema, and cerebral blood flow in acute focal cerebral ischemia in rats.},
  author={Rainer Kollmar and Thomas Frietsch and Dimitrios Georgiadis and Wolf-Ruediger Sch{\"a}bitz and Klaus F. Waschke and Wolfgang Kuschinsky and Stefan Schwab},
  journal={Anesthesiology},
  year={2002},
  volume={97 4},
  pages={
          868-74
        }
}
BACKGROUND Although the frequency for the use of moderate hypothermia in acute ischemic stroke is increasing, the optimal acid-base management during hypothermia remains unclear. This study investigates the effect of pH- and alpha-stat acid-base management on cerebral blood flow (CBF), infarct volume, and cerebral edema in a model of transient focal cerebral ischemia in rats. METHODS Twenty Sprague-Dawley rats were subjected to transient middle cerebral artery occlusion (MCAO) for 2 h during… CONTINUE READING

Citations

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Hypothermia and Cerebral Ischemia

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  • 2004
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Therapeutic hypothermia for acute ischemic stroke: ready to start large randomized trials?

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