Early effectiveness of heptavalent conjugate pneumococcal vaccination on invasive pneumococcal disease after the introduction in the Danish Childhood Immunization Programme.

@article{Harboe2010EarlyEO,
  title={Early effectiveness of heptavalent conjugate pneumococcal vaccination on invasive pneumococcal disease after the introduction in the Danish Childhood Immunization Programme.},
  author={Zitta Barrella Harboe and Palle Valentiner-Branth and Thomas Benfield and Jens J\orgen E Christensen and Peter Henrik Senten Andersen and Michael Frantz Howitz and Karen Angeliki Krogfelt and Lotte Lambertsen and Helle Bossen Konradsen},
  journal={Vaccine},
  year={2010},
  volume={28 14},
  pages={2642-7}
}
We evaluated the effectiveness of the heptavalent pneumococcal conjugate vaccine (PCV7) on invasive pneumococcal disease (IPD) 1 year after PCV7's introduction in the childhood immunization programme through a nationwide cohort study based on laboratory surveillance data. There was a decline in the overall incidence of IPD from 19.4 to 17.1 cases per 100,000 population (incidence rate ratios (IRR) 0.87; 95% confidence interval (CI) [0.81-0.96]), and of meningitis from 1.56 to 1.16 (IRR 0.74; 95… CONTINUE READING

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