Early effect of hyaluronic acid intra-articular injections on serum and urine biomarkers in patients with knee osteoarthritis: An open-label observational prospective study.

@article{Conrozier2012EarlyEO,
  title={Early effect of hyaluronic acid intra-articular injections on serum and urine biomarkers in patients with knee osteoarthritis: An open-label observational prospective study.},
  author={Thierry Conrozier and J. C. Balblanc and Pascal Richette and Denis Mulleman and Bernard Maillet and Yves Henrotin and Francois Patrick Rannou and Catherine Piroth and Pascal Hilliquin and Pierre A. Mathieu and Anne Walliser-Lohse and Isabelle Rousselot and Val{\'e}rie Plattner and J. F. Maillefert and Eric P. Vignon and Xavier Chevalier},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={2012},
  volume={30 5},
  pages={
          679-85
        }
}
The aim of the study was to investigate the effect of hyaluronic acid (HA) intra articular injections (IA) on osteoarthritis (OA) biomarkers in patients with knee OA. Prospective open label study. Fifty-one patients with unilateral symptomatic K-OA received IA injections of 2mL of HA on days (D) 1, 7, 14 and were followed 3 months. At D-15 patients were examined and X-rays performed, to exclude patients with bilateral K-OA, or those with more than three symptomatic OA joints. From 15 days (D-15… CONTINUE READING
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