Early downregulation of Mcl-1 regulates apoptosis triggered by cardiac glycoside UNBS1450

@inproceedings{Cerella2015EarlyDO,
  title={Early downregulation of Mcl-1 regulates apoptosis triggered by cardiac glycoside UNBS1450},
  author={C Cerella and Florian Muller and Anthoula Gaigneaux and Flavia Radogna and Elodie Viry and S{\'e}bastien Chateauvieux and Mario A. Dicato and Marc Diederich},
  booktitle={Cell Death and Disease},
  year={2015}
}
Cardiac glycosides (CGs), prescribed to treat cardiovascular alterations, display potent anti-cancer activities. Despite their well-established target, the sodium/potassium (Na+/K+)-ATPase, downstream mechanisms remain poorly elucidated. UNBS1450 is a hemi-synthetic cardenolide derived from 2″-oxovorusharin extracted from the plant Calotropis procera, which is effective against various cancer cell types with an excellent differential toxicity. By comparing adherent and non-adherent cancer cell… CONTINUE READING