Early diffusion-weighted MRI as a predictor of caspase-3 activation after hypoxic-ischemic insult in neonatal rodents.

@article{Wendland2008EarlyDM,
  title={Early diffusion-weighted MRI as a predictor of caspase-3 activation after hypoxic-ischemic insult in neonatal rodents.},
  author={M. Wendland and Joel V Faustino and Tim West and Catherine G Manabat and David M Holtzman and Zinaida S. Vexler},
  journal={Stroke},
  year={2008},
  volume={39 6},
  pages={1862-8}
}
BACKGROUND AND PURPOSE Neonatal encephalopathy in human babies is a serious condition associated with permanent neurological deficits. Diffusion-weighted MRI (DWI) is increasingly used for early diagnosis of brain injury in human babies. The relationship between the presence of DWI abnormalities and cellular injury, including apoptosis, during the neonatal period are not well understood. We asked whether the extent of injury depicted on DWI can predict the presence of caspase-3 activation, a… CONTINUE READING

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Minocycline confers early but transient protection in the immature brain following focal cerebral ischemia-reperfusion.

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