Early diabetes as a model for testing the regulation of juxtaglomerular NOS I.

@article{Thomson2004EarlyDA,
  title={Early diabetes as a model for testing the regulation of juxtaglomerular NOS I.},
  author={Scott C. Thomson and Aihua Deng and Norikuni Komine and John S Hammes and Roland C. Blantz and Francis B Gabbai},
  journal={American journal of physiology. Renal physiology},
  year={2004},
  volume={287 4},
  pages={F732-8}
}
Dysregulation of kidney nitric oxide synthase (NOS) I may alter renal hemodynamics in diabetes. Four types of studies were performed in anesthetized 1- to 2-wk-streptozotocin diabetic rats. 1) Glomerular filtration rate (GFR) was measured before and during NOS I blockade. Subsequent addition of nonspecific NOS blocker tested for residual NO from other… CONTINUE READING