Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2

@article{Guillam1997EarlyDA,
  title={Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2},
  author={Marie-Thérèse Guillam and Edith H{\"u}mmler and E. Schaerer and J.-Y Wu and M. Birnbaum and F. Beermann and A. Schmidt and N. D{\'e}riaz and B. Thorens},
  journal={Nature Genetics},
  year={1997},
  volume={17},
  pages={327-330}
}
  • Marie-Thérèse Guillam, Edith Hümmler, +6 authors B. Thorens
  • Published 1997
  • Biology, Medicine
  • Nature Genetics
    • Glut-2 is a low-affinity transporter present in the plasma membrane of pancreatic (β-cells, hepatocytes and intestine and kidney absorptive epithelial cells of mice1. In β-cells, Glut-2 has been proposed to be active in the control of glucose-stimulated insulin secretion (GSIS; ref. 2), and its expression is strongly reduced in glucose-unresponsive islets from different animal models of diabetes2–4. However, recent investigations have yielded conflicting data on the possible role of Glut-2 in… CONTINUE READING
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