Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2

  title={Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2},
  author={Marie-Thérèse Guillam and Edith H{\"u}mmler and E. Schaerer and J.-Y Wu and M. Birnbaum and F. Beermann and A. Schmidt and N. D{\'e}riaz and B. Thorens},
  journal={Nature Genetics},
  • Marie-Thérèse Guillam, Edith Hümmler, +6 authors B. Thorens
  • Published 1997
  • Biology, Medicine
  • Nature Genetics
  • Glut-2 is a low-affinity transporter present in the plasma membrane of pancreatic (β-cells, hepatocytes and intestine and kidney absorptive epithelial cells of mice1. In β-cells, Glut-2 has been proposed to be active in the control of glucose-stimulated insulin secretion (GSIS; ref. 2), and its expression is strongly reduced in glucose-unresponsive islets from different animal models of diabetes2–4. However, recent investigations have yielded conflicting data on the possible role of Glut-2 in… CONTINUE READING
    256 Citations
    Insulinoma induces a hyperinsulinemia-mediated decrease of GLUT2 and GLP1 receptor in normal pancreatic β-cells.
    Hypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice
    • 440
    Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice.
    • 66
    Distinct Classes of Central GLUT2-Dependent Sensors Control Counterregulation and Feeding
    • 18
    • PDF
    Glyco-Predisposing Factor of Diabetes
    • 2
    WASH Regulates Glucose Homeostasis by Facilitating Glut2 Receptor Recycling in Pancreatic β-Cells
    • 6
    • PDF
    Glucose transporters in pancreatic islets
    • 4
    • Highly Influenced
    • PDF


    Expression of GLUT-2 antisense RNA in beta cells of transgenic mice leads to diabetes.
    • 89
    Reduced expression of the liver/beta-cell glucose transporter isoform in glucose-insensitive pancreatic beta cells of diabetic rats.
    • 141
    [Val12] HRAS downregulates GLUT2 in beta cells of transgenic mice without affecting glucose homeostasis.
    • M. Tal, Y. Wu, +5 authors S. Efrat
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1992
    • 35
    • PDF
    Molecular and cellular physiology of GLUT-2, a high-Km facilitated diffusion glucose transporter.
    • B. Thorens
    • Biology, Medicine
    • International review of cytology
    • 1992
    • 119
    Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression.
    • 370
    • PDF
    Beta cells arise from glucose transporter type 2 (Glut2)-expressing epithelial cells of the developing rat pancreas.
    • 147
    • PDF