Early dexamethasone treatment induces placental apoptosis in sheep.

@article{Braun2015EarlyDT,
  title={Early dexamethasone treatment induces placental apoptosis in sheep.},
  author={Thorsten V. Braun and Wenbin Meng and Hongkai Shang and Shaofu Li and Deborah M Sloboda and Loreen Ehrlich and Karolin Lange and Huaisheng Xu and Wolfgang Henrich and Joachim Wolfram Dudenhausen and Andreas Plagemann and John P. Newnham and John R. G. Challis},
  journal={Reproductive sciences},
  year={2015},
  volume={22 1},
  pages={
          47-59
        }
}
Glucocorticoid treatment given in late pregnancy in sheep resulted in altered placental development and function. An imbalance of placental survival and apoptotic factors resulting in an increased rate of apoptosis may be involved. We have now investigated the effects of dexamethasone (DEX) in early pregnancy on binucleate cells (BNCs), placental apoptosis, and fetal sex as a determinant of these responses. Pregnant ewes carrying singleton fetuses (n = 105) were randomized to control (n = 56, 2… CONTINUE READING
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Effects of glucocorticoid treatment given in early or late gestation on growth and development in sheep.

  • Journal of developmental origins of health and disease
  • 2013
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