Early development of the metabolic syndrome after chemotherapy for testicular cancer.

  title={Early development of the metabolic syndrome after chemotherapy for testicular cancer.},
  author={Esther C. de Haas and Renske Altena and Hendrika M. Boezen and Nynke Zwart and Andries J. Smit and Stephan J L Bakker and Arie M. van Roon and A Postma and Bruce H. R. Wolffenbuttel and Harald Joan Hoekstra and Floor E. van Leeuwen and Dirk Th Sleijfer and Jourik A. Gietema},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  volume={24 3},
BACKGROUND The metabolic syndrome (MS) might increase the risk of cardiovascular disease in testicular cancer (TC) survivors. We investigated its prevalence, development, vascular implications, and the role of gonadal function. METHODS TC survivors treated with chemotherapy and follow-up ≥3 years (N = 370, study I) were retrospectively evaluated for the development of cardiovascular risk factors. A subgroup followed 3-20 years (N = 173, study II) was compared with controls (N = 1085) for MS… CONTINUE READING
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