Early development in Williams syndrome

  title={Early development in Williams syndrome},
  author={S. Tsai and Shyi-Kuen Wu and Y. Liou and S. Shu},
  journal={Pediatrics International},
Background: The aim of the present study was to gain a better understanding of the motor performance in Williams syndrome for early intervention of rehabilitation programs. 
Motor Abilities and the Motor Profile in Individuals with Williams Syndrome
Objectives Motor difficulties are present across a range of neurodevelopmental disorders, impacting on the development of other domains and on overall quality of life. One population that showsExpand
Motor performance of children with mild intellectual disability and borderline intellectual functioning.
The results support the notion that the level of motor and cognitive functioning are related in children with ID, and the importance of improving motor skill performance in both children with borderline and mild ID is highlighted. Expand
The effect of adding a home program to weekly institutional‐based therapy for children with undefined developmental delay: A pilot randomized clinical trial
Early intervention programs are helpful for children with developmental delay without defined etiology, and the addition of structured home activity programs may augment the effects on developmental progression. Expand
Williams syndrome: A surprising deficit in oromotor praxis in a population with proficient language production
The findings suggest that the ability to plan, co-ordinate and execute complex sensorimotor movements contribute to an explanation of the delay in expressive language early in development in this neurodevelopmental disorder. Expand
Differences in age-related effects on brain volume in Down syndrome as compared to Williams syndrome and typical development
Individuals with Down Syndrome demonstrated a unique pattern of age-related effects on gray matter and ventricular volume, the latter of which was associated with dementia rating scores in the DS group. Expand
Sensorimotor and visual perceptual functioning in school‐aged children with Williams syndrome
The findings characterised the profiles of body functions (sensorimotor functions and visual organisation) of children with DS, and revealed their correlations with activity participation. Expand
A kinematic analysis of visually-guided movement in Williams syndrome
The results indicate that the visuomotor coordination deficits in WS may reflect known impairments of the dorsal stream, but may also indicate a role for the cerebellum in dynamic feed-forward motor control. Expand
Capacity to improve fine motor skills in Williams syndrome.
Estimating motor learning capacity and the depth of sleep disorder in a larger sample of WS individuals might reveal important relationships between sleep and learning, and contribute to efficient intervention methods improving skill acquisition in WS. Expand
Listening to Parents’ Concerns: Three Case Examples of Infants with Developmental Motor Delays
  • S. Harris
  • Psychology, Medicine
  • Pediatric physical therapy : the official publication of the Section on Pediatrics of the American Physical Therapy Association
  • 2009
Compared parents’ concerns about their infants’ suspected motor delays with scores on the Harris Infant Neuromotor Test and the Bayley-II Motor Scale to determine whether there was agreement in categorizing the delays on the 2 tests. Expand
Cross-Domain Associations Between Motor Ability, Independent Exploration, and Large-Scale Spatial Navigation; Attention Deficit Hyperactivity Disorder, Williams Syndrome, and Typical Development
The motor-spatial relationship in the TD, but not the ADHD and WS groups, suggests that aspects of spatial cognition can develop via a developmental pathway which bypasses input from the motor domain. Expand


Motor Performance Checklist for 5‐year‐olds: A tool for identifying children at risk of developmental co‐ordination disorder
Objective:  The aim of this study was to further evaluate the ‘Motor Performance Checklist for 5‐year‐olds’, an instrument which had been piloted with some success and reported via this journal inExpand
Natural history of Williams syndrome: physical characteristics.
A growth pattern characterized by delay in the first 4 years of life, catch-up growth in childhood, and low ultimate adult height was found, indicating Williams syndrome is a progressive disorder with multisystem involvement. Expand
Williams Syndrome: Neuropsychological Findings and Implications for Practice
Williams syndrome (WS) is a genetic disorder resulting from a deletion on Chromosome 7. Individuals with WS exhibit distinct physical features such as facial abnormalities, hypercalcemia, andExpand
Cognitive functioning in adults with Williams syndrome.
Differences between Verbal and Performance IQ, and between receptive and expressive language skills, were smaller than generally found in studies of children with this condition, but an examination of subtest scores revealed an almost identical cognitive profile to that found in children. Expand
Early development (5 to 48 months) in Williams syndrome. A study of 14 children.
Analysis of information gathered over a five year period provided an outline for "developmental norms" for children with Williams syndrome and concluded that, even before the age of 4 years, children with WS display a typical profile in their abilities. Expand
Williams syndrome in adults.
The patients in this study were very variable in clinical presentation, ranging from severely affected patients with complicated medical histories to mildly affected patients who are generally in good health. Expand
Neurologic Findings in Children and Adults With Williams Syndrome
Twenty-four children with Williams syndrome underwent systematic neurologic evaluations. Abnormalities of mental status, motor coordination, tone, and gait were most prevalent. Tone abnormalitiesExpand
Verbal and nonverbal abilities in the Williams syndrome phenotype: evidence for diverging developmental trajectories.
It is suggested that these results are best explained in terms of verbal ability developing at a faster rate than nonverbal ability in this disorder, and how this model of differential rates of development has the potential to reconcile the apparently inconsistent findings in this area. Expand
Williams syndrome: cognition, personality, and adaptive behavior.
The adaptive behavior profile for Williams syndrome involves clear strength in socialization skills (especially interpersonal skills related to initiating social interaction), strength in communication, and clear weakness in daily living skills and motor skills, relative to overall level of adaptive behavior functioning. Expand
Visual and visuospatial development in young children with Williams syndrome.
Results confirm the dissociation between visuospatial and language abilities in children with Williams' syndrome, and support the neurobiological model of a split between ventral and dorsal stream processing of visual information with a generalized deficit in dorsal streamprocessing in young children with WS. Expand