Early detection strategies for untreated first-episode psychosis

@article{Johannessen2001EarlyDS,
  title={Early detection strategies for untreated first-episode psychosis},
  author={Jan Olav Johannessen and Thomas H. McGlashan and Tor Ketil Larsen and Marthe Horneland and Inge Joa and Sigurd Mardal and Rune Kveb{\ae}k and Svein Friis and Ingrid Melle and Stein Opjordsmoen and Erik Simonsen and Haahr Ulrik and Per Wiggen Vaglum},
  journal={Schizophrenia Research},
  year={2001},
  volume={51},
  pages={39-46}
}
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TLDR
Early treatment had positive effects on clinical and functional status at 5-year follow-up in first episode psychosis and could be explained by confounders.
Early detection of first-episode psychosis: the effect on 1-year outcome.
TLDR
The ED, no-ED differences at baseline become attenuated by 1 year but not the difference in negative symptoms, suggesting secondary prevention in this domain of psychopathology, however, this possibility requires further testing by follow-up and replication.
The key to reducing duration of untreated first psychosis: information campaigns.
TLDR
Intensive education campaigns toward the general public, the schools, and the primary health care services appear to be an important and necessary part of an early detection program.
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TLDR
A community-wide approach to early case identification may not be the most effective way to reduce delay in treatment of psychosis, but may bring into treatment patients who have been ill for long periods of time and have a higher level of psychopathology.
A community intervention for early identification of First Episode Psychosis
TLDR
A community-wide approach to early case identification may not be the most effective way to reduce delay in treatment of psychosis, but may bring into treatment patients who have been ill for long periods of time and have a higher level of psychopathology.
Shortened duration of untreated first episode of psychosis: changes in patient characteristics at treatment.
TLDR
Early detection can shorten duration of untreated psychosis and help more patients when they are less severely ill, this is a significant treatment advance.
Early Detection of Ultra High Risk for Psychosis in a Norwegian Catchment Area: The Two Year Follow-Up of the Prevention of Psychosis Study
TLDR
Whether a systematic early detection program, modeled after the successful early detection of psychosis program TIPS, would improve the detection of help-seeking UHR individuals and the rates and predictors of conversion to psychosis after 2 years is examined.
Pathways to care for first-episode psychosis in an early detection healthcare sector
TLDR
After establishing low threshold active case-seeking detection teams, clear differences are found between those patients entering treatment via detection teams v. those obtaining treatment via the usual channels.
First-episode psychosis: An update
TLDR
The literature on first-episode psychosis is reviewed and a resurgence of interest in psychosocial risk factors for the development of schizophrenia in the recent literature is highlighted.
The outcome of early intervention in first episode psychosis
TLDR
An overview of the most important trials and evidence regarding the outcome of early intervention in first episode psychosis shows both elements appear necessary in order to develop an integrated service that can provide the optimal treatment for patients with FEP.
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References

SHOWING 1-10 OF 27 REFERENCES
First-episode schizophrenia with long duration of untreated psychosis: Pathways to care
TLDR
It seems to be important to educate the social network related to the individual about the importance of early treatment and to identify people earlier, a system of detection must be mobile, easily accessible and attentive to early symptoms of psychosis.
First-episode schizophrenia: I. Early course parameters.
TLDR
Early course parameters of a Norwegian first-episode sample demonstrated strong gender differences, with male patients having significantly higher frequency of single marital status, lower educational status, schizophrenia, early age at onset, and lower Global Assessment of Functioning scores the last year before hospitalization.
Early detection and intervention in schizophrenia
TLDR
It appears, however, that the addition of a behavioural family intervention alone to a standard programme offers little additional benefit and patients should continue with such intensive treatment strategies for at least the duration of the critical phase.
Causes and consequences of duration of untreated psychosis in schizophrenia.
TLDR
Longer DUP results partly from a pattern of symptoms and social functioning which reduces concern by the sufferer and relevant others, and has implications for targeting early intervention.
EPPIC: an evolving system of early detection and optimal management.
TLDR
A framework for preventive intervention in early psychosis is outlined, based on more than a decade of experience initially gained within a first-generation model, a comprehensive "real-world" model of care targeting the multiple clinical foci underpinning the preventive task.
Duration of psychosis and outcome in first-episode schizophrenia.
TLDR
Duration of psychosis before treatment may be an important predictor of outcome in first-episode schizophrenia, and is significantly associated with time to remission as well as with level of remission.
Early detection and intervention with schizophrenia: rationale.
TLDR
The evidence to date does not demonstrate that early intervention with known treatments can change the natural history of schizophrenia, but it is suggestive enough (for both biological and psychosocial treatment) to support further investigation.
Early detection and intervention in schizophrenia: research.
TLDR
Greater attention is needed on the early course of schizophrenia, including defining and describing early course, detecting cases early at onset or in the prodrome, testing whether early detection and treatment enhances treatment response and prognosis, and predicting at-risk cases early in the propromal phase.
Premorbid and onset features of first-episode schizophrenia.
TLDR
Systematic characterization of the earliest manifestations of schizophrenia may be important in identifying subgroups of patients with a similar course of illness, and may ultimately facilitate diagnosis, treatment, and understanding of the pathophysiology of schizophrenia.
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