Early detection of the chemical changes occurring during the induction and prevention of autoimmune-mediated demyelination detected by FT-IR imaging

@article{Heraud2010EarlyDO,
  title={Early detection of the chemical changes occurring during the induction and prevention of autoimmune-mediated demyelination detected by FT-IR imaging},
  author={Philip Heraud and Sally Caine and Naomi Campanale and Tara Karnezis and Donald McNaughton and Bayden R. Wood and Mark J. Tobin and Claude C. A. Bernard},
  journal={NeuroImage},
  year={2010},
  volume={49 2},
  pages={1180-9}
}
Multiple sclerosis (MS) is an inflammatory, demyelinating and neurodegenerative disease of the central nervous system (CNS). Despite progress in understanding immunogenetic aspects of this disease, the mechanisms involved in lesion formation are unknown. To gain new insights into the neuropathology of MS, we used an innovative integration of Fourier transform infrared (FT-IR) microspectroscopy, bioinformatics, and a synchrotron light source to analyze macromolecular changes in the CNS during… CONTINUE READING