Early detection of response in small cell bronchogenic carcinoma by changes in serum concentrations of creatine kinase, neuron specific enolase, calcitonin, ACTH, serotonin and gastrin releasing peptide.

@article{Bork1988EarlyDO,
  title={Early detection of response in small cell bronchogenic carcinoma by changes in serum concentrations of creatine kinase, neuron specific enolase, calcitonin, ACTH, serotonin and gastrin releasing peptide.},
  author={E Bork and Mogens Hansen and Petter Urdal and Elisabeth Paus and Jens Juul Holst and S\oren Schifter and Mogens Fenger and Frode Engbaek},
  journal={European journal of cancer & clinical oncology},
  year={1988},
  volume={24 6},
  pages={1033-8}
}
Creatine kinase (CK-BB), neuron specific enolase (NSE), ACTH, calcitonin, serotonin and gastrin releasing peptide (GRP) were measured in serum or plasma before and immediately after initiation of treatment in patients with small cell lung cancer (SCC). Pretherapeutic elevated concentrations of CK-BB were found in 82% of extensive disease patients and in 50% of patients with local disease. NSE was raised in 72% with extensive disease versus 14% of patients with local disease. Calcitonin and ACTH… CONTINUE READING