Early detection of nephrotoxic effects in thalassemic patients receiving desferrioxamine therapy.

@article{Cianciulli1994EarlyDO,
  title={Early detection of nephrotoxic effects in thalassemic patients receiving desferrioxamine therapy.},
  author={Paolo Cianciulli and D Sollecito and Francesco Sorrentino and Lindy Forte and Emanuele Gilardi and Ant{\'o}nio Augusto Fernandes Massa and Giuseppe Papa and Serafino Carta},
  journal={Kidney international},
  year={1994},
  volume={46 2},
  pages={467-70}
}
Nineteen transfusion-dependent beta-thalassemia major patients were included in the study. Six of these patients underwent chelation therapy with desferrioxamine by subcutaneous infusion (50 mg/kg/12 hr) and 13 received intravenous infusion (50 mg/kg/6 hr or 100 mg/kg/24 hr). BUN, creatinine, creatinine clearance, beta 2-microglobulin, urinary beta 2-microglobulin and urinary growth hormone excretion were evaluated during desferrioxamine treatment. Thirteen out of nineteen patients presented… CONTINUE READING

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