Early detection of breast cancer based on gene-expression patterns in peripheral blood cells

@article{Sharma2005EarlyDO,
  title={Early detection of breast cancer based on gene-expression patterns in peripheral blood cells},
  author={Praveen Sharma and Narinder Singh Sahni and Robert Tibshirani and Per Skaane and Petter Urdal and Hege Berghagen and Marianne Jensen and Lena Iren Kristiansen and Cecilie Moen and Pradeep Sharma and Alia Zaka and Jarle Birger Arnes and Torill Sauer and Lars Andreas Akslen and Ellen Schlichting and Anne-Lise B\orresen-Dale and Anders L{\"o}nneborg},
  journal={Breast Cancer Research},
  year={2005},
  volume={7},
  pages={R634 - R644}
}
Existing methods to detect breast cancer in asymptomatic patients have limitations, and there is a need to develop more accurate and convenient methods. In this study, we investigated whether early detection of breast cancer is possible by analyzing gene-expression patterns in peripheral blood cells. Using macroarrays and nearest-shrunken-centroid method, we analyzed the expression pattern of 1,368 genes in peripheral blood cells of 24 women with breast cancer and 32 women with no signs of this… CONTINUE READING