Early detection and monitoring of cartilage alteration in the experimental meniscectomised guinea pig model of osteoarthritis by 99mTc-NTP 15-5 scintigraphy

This study in the meniscectomised guinea pig aimed to demonstrate that the radiotracer 99mTc-NTP 15-5 would have pathophysiological validity for in vivo osteoarthritis imaging. The specificity of 99mTc-NTP 15-5 for cartilage was determined in healthy animals (n = 13), by tissue radioactivity counting, joint autoradiography and scintigraphy. 99mTc-NTP 15-5… CONTINUE READING