Early decisions in lymphoid development.

@article{Ye2007EarlyDI,
  title={Early decisions in lymphoid development.},
  author={Min Ye and Thomas Graf},
  journal={Current opinion in immunology},
  year={2007},
  volume={19 2},
  pages={123-8}
}
Recent research suggests that lymphoid progenitors in the bone marrow comprise a heterogeneous cell population. This population first loses megakaryocyte/erythroid, and then granulocyte/macrophage, potential before committing to lymphoid lineages. B and T cells can originate by way of different pathways that appear to be used with varying frequencies in the animal. In the bone marrow, B cell specification and commitment is driven by the concerted action of transcription factors and IL-7… CONTINUE READING

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