Early decisions in lymphoid development.

  title={Early decisions in lymphoid development.},
  author={Min Ye and Thomas Graf},
  journal={Current opinion in immunology},
  volume={19 2},
Recent research suggests that lymphoid progenitors in the bone marrow comprise a heterogeneous cell population. This population first loses megakaryocyte/erythroid, and then granulocyte/macrophage, potential before committing to lymphoid lineages. B and T cells can originate by way of different pathways that appear to be used with varying frequencies in the animal. In the bone marrow, B cell specification and commitment is driven by the concerted action of transcription factors and IL-7… CONTINUE READING

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