Early cytoskeletal changes as shown by Alz-50 are not accompanied by decreased neuronal activity.

@article{Salehi1995EarlyCC,
  title={Early cytoskeletal changes as shown by Alz-50 are not accompanied by decreased neuronal activity.},
  author={Ahmad Salehi and J A P van de Nes and Michel A. Hofman and Nicholas K. Gonatas and Dick F. Swaab},
  journal={Brain research},
  year={1995},
  volume={678 1-2},
  pages={28-39}
}
The nucleus tuberalis lateralis (NTL) is located in the basolateral part of the hypothalamus and is only present as a well-delineated nucleus in human and higher primates. In Alzheimer's disease (AD), NTL neurons show strong early cytoskeletal alterations, as revealed by the antibody Alz-50, but practically no senile plaques or neurofibrillary tangles. To study whether the activity of NTL neurons decreases when cytoskeletal changes appear, i.e., during aging and in AD, we applied a polyclonal… CONTINUE READING