Early cryoprecipitate for major haemorrhage in trauma: a randomised controlled feasibility trial.

@article{Curry2015EarlyCF,
  title={Early cryoprecipitate for major haemorrhage in trauma: a randomised controlled feasibility trial.},
  author={Nicola S Curry and Claire Rourke and Ross A Davenport and S. A. de Beer and Laura Pankhurst and Alison Deary and Hartmut Thomas and Charlotte A Llewelyn and Laura Green and Heidi Doughty and Giles R Nordmann and Karim Brohi and Simon J Stanworth},
  journal={British journal of anaesthesia},
  year={2015},
  volume={115 1},
  pages={76-83}
}
BACKGROUND Low fibrinogen (Fg) concentrations in trauma haemorrhage are associated with poorer outcomes. Cryoprecipitate is the standard source for Fg administration in the UK and USA and is often given in the later stages of transfusion therapy. It is not known whether early cryoprecipitate therapy improves clinical outcomes. The primary aim of this feasibility study was to determine whether it was possible to administer cryoprecipitate, within 90 min of admission to hospital. Secondary aims… CONTINUE READING

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This was an unblinded RCT , conducted at two civilian UK major trauma centres of adult trauma patients ( age ≥16 yrs ) , with active bleeding and requiring activation of the major haemorrhage protocol .
This was an unblinded RCT , conducted at two civilian UK major trauma centres of adult trauma patients ( age ≥16 yrs ) , with active bleeding and requiring activation of the major haemorrhage protocol .
This was an unblinded RCT , conducted at two civilian UK major trauma centres of adult trauma patients ( age ≥16 yrs ) , with active bleeding and requiring activation of the major haemorrhage protocol .
This was an unblinded RCT , conducted at two civilian UK major trauma centres of adult trauma patients ( age ≥16 yrs ) , with active bleeding and requiring activation of the major haemorrhage protocol .
Early cryoprecipitate for major haemorrhage in trauma : a randomised controlled feasibility trial .
This was an unblinded RCT , conducted at two civilian UK major trauma centres of adult trauma patients ( age ≥16 yrs ) , with active bleeding and requiring activation of the major haemorrhage protocol .
This was an unblinded RCT , conducted at two civilian UK major trauma centres of adult trauma patients ( age ≥16 yrs ) , with active bleeding and requiring activation of the major haemorrhage protocol .
This was an unblinded RCT , conducted at two civilian UK major trauma centres of adult trauma patients ( age ≥16 yrs ) , with active bleeding and requiring activation of the major haemorrhage protocol .
This was an unblinded RCT , conducted at two civilian UK major trauma centres of adult trauma patients ( age ≥16 yrs ) , with active bleeding and requiring activation of the major haemorrhage protocol .
Early cryoprecipitate for major haemorrhage in trauma : a randomised controlled feasibility trial .
This was an unblinded RCT , conducted at two civilian UK major trauma centres of adult trauma patients ( age ≥16 yrs ) , with active bleeding and requiring activation of the major haemorrhage protocol .
This was an unblinded RCT , conducted at two civilian UK major trauma centres of adult trauma patients ( age ≥16 yrs ) , with active bleeding and requiring activation of the major haemorrhage protocol .
This was an unblinded RCT , conducted at two civilian UK major trauma centres of adult trauma patients ( age ≥16 yrs ) , with active bleeding and requiring activation of the major haemorrhage protocol .
This was an unblinded RCT , conducted at two civilian UK major trauma centres of adult trauma patients ( age ≥16 yrs ) , with active bleeding and requiring activation of the major haemorrhage protocol .
Early cryoprecipitate for major haemorrhage in trauma : a randomised controlled feasibility trial .
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