Early cortical thickness changes predict β-amyloid deposition in a mouse model of Alzheimer's disease.

@article{Grandmaison2013EarlyCT,
  title={Early cortical thickness changes predict β-amyloid deposition in a mouse model of Alzheimer's disease.},
  author={Marilyn Grand'maison and Simone P. Zehntner and Ming-Kai Ho and Francois Olivier Hebert and Andrew Wood and Felix Carbonell and Alex P. Zijdenbos and Edith Hamel and Barry J. Bedell},
  journal={Neurobiology of disease},
  year={2013},
  volume={54},
  pages={59-67}
}
Magnetic resonance imaging (MRI) studies have identified aberrant cortical structure in Alzheimer's disease (AD). The association between MRI-derived cortical morphometry measures and β-amyloid, however, remains poorly understood. In this study, we explored the potential relationship between early alterations in cortical thickness and later stage β-amyloid deposition, using a novel approach, in a transgenic AD mouse model. We acquired longitudinal anatomical MRI scans from mutant amyloid… CONTINUE READING