Early cognitive decline is associated with prion protein codon 129 polymorphism

  title={Early cognitive decline is associated with prion protein codon 129 polymorphism},
  author={E. Croes and B. Dermaut and J. Houwing-Duistermaat and M. van den Broeck and M. Cruts and M. Breteler and A. Hofman and C. van Broeckhoven and C. V. van Duijn},
  journal={Annals of Neurology},
  • E. Croes, B. Dermaut, +6 authors C. V. van Duijn
  • Published 2003
  • Biology, Medicine
  • Annals of Neurology
  • A common polymorphism in the gene encoding the prion protein (PRNP) is known to determine susceptibility to Creutzfeldt–Jakob disease. This polymorphism at codon 129 encodes for either methionine (M) or valine (V). There is an increasing interest in the role of this protein in other neurodegenerative processes including Alzheimer’s disease. Here, we address the question whether genetic variability of the PRNP codon 129 polymorphism plays an (agedependent) role in cognitive decline. PRNP codon… CONTINUE READING
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