Early clonality and high-frequency proviral integration into the c-myc locus in AKR leukemias.

@article{ODonnell1985EarlyCA,
  title={Early clonality and high-frequency proviral integration into the c-myc locus in AKR leukemias.},
  author={Pat O'Donnell and Erwin Fleissner and H K Lonial and C F Koehne and A S Reicin},
  journal={Journal of virology},
  year={1985},
  volume={55 2},
  pages={500-3}
}
Blot hybridization of thymocyte DNA from AKR/J mice was used to detect new proviral junction fragments as markers of clonality at different stages of viral leukemogenesis and to detect DNA rearrangements at the c-myc locus due to proviral insertion. Clonal populations of thymocytes were observed in mink cell focus-forming virus-injected mice as early as 35 days postinjection, at a stage distinguishable from frank leukemia by flow cytometric analysis and transplantation bioassay. Specific… CONTINUE READING

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