Early clinical PET imaging results with the novel PHF-tau radioligand [F18]-T808.

@article{Chien2014EarlyCP,
  title={Early clinical PET imaging results with the novel PHF-tau radioligand [F18]-T808.},
  author={David T. Chien and Anna Katrin Szardenings and S. el Bahri and Joseph C. Walsh and Fanrong Mu and Chunfang Xia and William Rodman Shankle and Alan J. Lerner and M F Su and Arkadij Elizarov and Hartmuth C. Kolb},
  journal={Journal of Alzheimer's disease : JAD},
  year={2014},
  volume={38 1},
  pages={171-84}
}
Aggregates of hyperphosphorylated tau (PHF-tau), such as neurofibrillary tangles, are linked to the degree of cognitive impairment in Alzheimer's disease. We have recently reported early clinical results of a novel PHF-tau targeting PET imaging agent, [F18]-T807. Since then, we have investigated a second novel PHF-tau targeting PET imaging agent, [F18]-T808, with different pharmacokinetic characteristics, which may be favorable for imaging Alzheimer's disease and other tauopathies. Here, we… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 21 references

Neuropathological stageing of Alzheimer-related changes

Acta Neuropathologica • 1991
View 10 Excerpts
Highly Influenced

A highly selective and specific PET tracer for imaging of tau pathologies.

Journal of Alzheimer's disease : JAD • 2012
View 2 Excerpts

The challenges of tau imaging

V Villemagne, S Furumoto, +7 authors N Okamura
Future Neurol • 2012
View 2 Excerpts

thesis and biological evaluation of novel oxindole derivatives for imaging neurofibrillary tangles in Alzheimer ’ s disease

V Villemagne, S Furumoto, +7 authors N Okamura
Bioorg Med Chem Lett • 2012

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