Early chromatin unfolding by RUNX1: a molecular explanation for differential requirements during specification versus maintenance of the hematopoietic gene expression program.

@article{Hoogenkamp2009EarlyCU,
  title={Early chromatin unfolding by RUNX1: a molecular explanation for differential requirements during specification versus maintenance of the hematopoietic gene expression program.},
  author={Maarten Hoogenkamp and Monika Lichtinger and Hanna Krysinska and Christophe Lancrin and Deborah L. Clarke and Andrew I. Williamson and Luca Mazzarella and Richard Ingram and Helle F. Jorgensen and Amanda L Fisher and Daniel G Tenen and Valerie Kouskoff and Georges Lacaud and Constanze Bonifer},
  journal={Blood},
  year={2009},
  volume={114 2},
  pages={299-309}
}
At the cellular level, development progresses through successive regulatory states, each characterized by their specific gene expression profile. However, the molecular mechanisms regulating first the priming and then maintenance of gene expression within one developmental pathway are essentially unknown. The hematopoietic system represents a powerful experimental model to address these questions and here we have focused on a regulatory circuit playing a central role in myelopoiesis: the… CONTINUE READING