Early childhood infections precede development of beta-cell autoimmunity and type 1 diabetes in children with HLA-conferred disease risk.

@article{Mustonen2018EarlyCI,
  title={Early childhood infections precede development of beta-cell autoimmunity and type 1 diabetes in children with HLA-conferred disease risk.},
  author={N Mustonen and Heli Siljander and Aleksandr Peet and Vallo Tillmann and Taina H{\"a}rk{\"o}nen and Jorma Ilonen and Heikki Hy{\"o}ty and Mikael Knip},
  journal={Pediatric diabetes},
  year={2018},
  volume={19 2},
  pages={293-299}
}
BACKGROUND The etiology of type 1 diabetes (T1D) is largely unknown. Infections and microbial exposures are believed to play a role in the pathogenesis and in the development of islet autoimmunity in genetically susceptible individuals. OBJECTIVE To assess the relationships between early childhood infections, islet autoimmunity, and progression to T1D in genetically predisposed children. METHODS Children with human leukocyte antigen (HLA)-conferred disease susceptibility (N=790; 51.5% males… CONTINUE READING
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Coxsackievirus B 1 is associated with induction of beta - cell autoimmunity that portends type 1

  • OH Laitinen, H Honkanen, O Pakkanen
  • DIABETES
  • 2014

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