Early changes of brain connectivity in primary open angle glaucoma.

@article{Frezzotti2016EarlyCO,
  title={Early changes of brain connectivity in primary open angle glaucoma.},
  author={Paolo Frezzotti and Antonio Giorgio and Francesca Toto and Alessandro De Leucio and A Giorgio},
  journal={Human brain mapping},
  year={2016},
  volume={37 12},
  pages={4581-4596}
}
Our aim was to assess in primary open angle glaucoma (POAG), a major cause of irreversible blindness worldwide, whether diffuse brain changes recently shown in advanced stage can be detected since the early stage. We used multimodal magnetic resonance imaging (MRI) in 57 patients with the three POAG stages and in 29 age-matched normal controls (NC). Voxelwise statistics was performed with nonparametric permutation testing. Compared with NC, disrupted anatomical connectivity (AC) was found in… CONTINUE READING
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