Early changes in rat hearts with developing pulmonary arterial hypertension can be detected with three-dimensional electrocardiography.

@article{Henkens2007EarlyCI,
  title={Early changes in rat hearts with developing pulmonary arterial hypertension can be detected with three-dimensional electrocardiography.},
  author={I. Henkens and K. T. B. Mouchaers and H. Vliegen and W. J. van der Laarse and C. A. Swenne and A. Maan and H. Draisma and I. Schalij and E. E. van der Wall and M. Schalij and A. Vonk-Noordegraaf},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2007},
  volume={293 2},
  pages={
          H1300-7
        }
}
  • I. Henkens, K. T. B. Mouchaers, +8 authors A. Vonk-Noordegraaf
  • Published 2007
  • Medicine
  • American journal of physiology. Heart and circulatory physiology
  • The study aim was to assess three-dimensional electrocardiogram (ECG) changes during development of pulmonary arterial hypertension (PAH). PAH was induced in male Wistar rats (n = 23) using monocrotaline (MCT; 40 mg/kg sc). Untreated healthy rats served as controls (n = 5). ECGs were recorded with an orthogonal three-lead system on days 0, 14, and 25 and analyzed with dedicated computer software. In addition, left ventricular (LV)-to-right ventricular (RV) fractional shortening ratio was… CONTINUE READING
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