Early changes in muscle fiber size and gene expression in response to spinal cord transection and exercise.

@article{DupontVersteegden1998EarlyCI,
  title={Early changes in muscle fiber size and gene expression in response to spinal cord transection and exercise.},
  author={Esther E Dupont-Versteegden and John D. Houl{\'e} and Cathy M Gurley and Charlotte A. Peterson},
  journal={American journal of physiology. Cell physiology},
  year={1998},
  volume={275 4},
  pages={C1124-C1133}
}
Muscles of spinal cord-transected rats exhibit severe atrophy and a shift toward a faster phenotype. Exercise can partially prevent these changes. The goal of this study was to investigate early events involved in regulating the muscle response to spinal transection and passive hindlimb exercise. Adult female Sprague-Dawley rats were anesthetized, and a complete spinal cord transection lesion (T10) was created in all rats except controls. Rats were killed 5 or 10 days after transection or they… CONTINUE READING

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