Early changes in morphology, bone mineral density and matrix composition of vertebrae lead to disc degeneration in aged collagen IX -/- mice.

@article{Kamper2016EarlyCI,
  title={Early changes in morphology, bone mineral density and matrix composition of vertebrae lead to disc degeneration in aged collagen IX -/- mice.},
  author={Matthias Kamper and Nina Hamann and Carina Prein and Hauke Clausen-Schaumann and Zsuzsanna Farkas and Attila Aszodi and Anja Niehoff and Mats Paulsson and Frank Zaucke},
  journal={Matrix biology : journal of the International Society for Matrix Biology},
  year={2016},
  volume={49},
  pages={132-143}
}
Collagen IX (Col IX) is an important component of the cartilage extracellularmatrix and has been associated with degenerative cartilage disorders and chondrodysplasias in humans. Further, polymorphisms in Col IX are known risk factors for the development of early intervertebral disc (IVD) degeneration. To understand the role of Col IX in the pathogenesis of… CONTINUE READING