Early changes in insulin secretion and action induced by high-fat diet are related to a decreased sympathetic tone.

@article{CrucianiGuglielmacci2005EarlyCI,
  title={Early changes in insulin secretion and action induced by high-fat diet are related to a decreased sympathetic tone.},
  author={C{\'e}line Cruciani-Guglielmacci and M Vincent-Lamon and C. D. V. Rouch and Martine Orosco and Alain Ktorza and Cathy Magnan},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2005},
  volume={288 1},
  pages={E148-54}
}
To evaluate the relationship between the development of obesity, nervous system activity, and insulin secretion and action, we tested the effect of a 2-mo high-fat diet in rats (HF rats) on glucose tolerance, glucose-induced insulin secretion (GIIS), and glucose turnover rate compared with chow-fed rats (C rats). Moreover, we measured pancreatic and hepatic norepinephrine (NE) turnover, as assessment of sympathetic tone, and performed hypothalamic microdialysis to quantify extracellular NE… CONTINUE READING
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