Early changes in hepatic redox homeostasis following treatment with a single dose of valproic acid.

@article{Cotariu1990EarlyCI,
  title={Early changes in hepatic redox homeostasis following treatment with a single dose of valproic acid.},
  author={Dita Cotariu and Sandra K. Evans and Jeffrey Zaidman and Otto-Walter Marcus},
  journal={Biochemical pharmacology},
  year={1990},
  volume={40 3},
  pages={589-93}
}
Changes in reduced glutathione (GSH) and pyridine nucleotide phosphate levels as well as in the activities of the glutathione peroxidase-reductase system and glucose-6-phosphate dehydrogenase have been studied in rats after a single i.p. administration of various doses of valproic acid (VPA). GSH level decreased in a dose-dependent relation. At the end of 180 min GSH levels either returned to control limits (lower doses) or showed a tendency to normalize (higher doses). GSH loss was paralleled… CONTINUE READING
13 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

Similar Papers

Loading similar papers…