Early changes in beta-cell function and insulin pulsatility as predictors for type 2 diabetes.

Peripheral insulin concentrations oscillate because of insulin secretory bursts every 6-10 min, which are the main source of overall insulin release. Regulation of insulin secretion occurs by modification of the mass and to some extent the frequency of the individual insulin secretory bursts. This oscillatory pattern, which is important for insulin action… CONTINUE READING