Early cellular interactions and immune transcriptome profiles in human factor VIII-exposed hemophilia A mice.

Abstract

Essentials Initial immune cell interactions leading to factor (F) VIII immunity are not well characterized. We assessed cellular interactions and expression profiles in hemophilia A mice. MARCO+, followed by SIGLEC1+ and SIGNR1+ macrophages co-localize most with human FVIII. The splenic transcriptome highlights potential therapeutic targets to prevent… (More)
DOI: 10.1111/jth.13936

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