Early cellular events in colorectal carcinogenesis.

  title={Early cellular events in colorectal carcinogenesis.},
  author={Andrew G Renehan and Sarah T O'dwyer and Naseer H J Haboubi and Christopher S. Potten},
  journal={Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland},
  volume={4 2},
Colorectal cancer develops through a multistage process recognizable at a histopathological level by progression from normal mucosa to invasive carcinoma (the adenoma-carcinoma sequence). For many years, it has been hypothesized that increased cell proliferation in the colonic crypt represents the earliest recognizable stage in this sequence. This perspective is now changing. While several human studies have reported increased crypt cell proliferation in samples from at-risk patients, there are… CONTINUE READING
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