Early atheroma-derived agonists of peroxisome proliferator-activated receptor-γ trigger intramedial angiogenesis in a smooth muscle cell-dependent manner.

@article{HoTinNo2011EarlyAA,
  title={Early atheroma-derived agonists of peroxisome proliferator-activated receptor-γ trigger intramedial angiogenesis in a smooth muscle cell-dependent manner.},
  author={Beno{\^i}t Ho-Tin-No{\'e} and Julien Le Dall and Delphine Gomez and Liliane Louedec and Roger Vranckx and Morad El-Bouchtaoui and Luc Legr{\`e}s and Olivier Meilhac and Jean-Baptiste Michel},
  journal={Circulation research},
  year={2011},
  volume={109 9},
  pages={1003-14}
}
RATIONALE Neovascularization favors intraplaque hemorrhage and plaque rupture. Development of therapeutic strategies against atheromatous angiogenesis requires elucidation of its initiating factors. OBJECTIVE We investigated the contribution of smooth muscle cells (SMCs) and atheroma-derived lipids to the initiation of atheroma-associated neoangiogenesis. METHODS AND RESULTS Forty human aortic segments, each harvested from a different donor, were classified as healthy or as bearing early… CONTINUE READING
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