Early application of Met-RANTES ameliorates chronic allograft nephropathy.

@article{Song2002EarlyAO,
  title={Early application of Met-RANTES ameliorates chronic allograft nephropathy.},
  author={Erwei Song and Hequn Zou and Yousheng Yao and Amanda Proudfoot and Bal{\'a}zs Antus and Shanying Liu and Lutz Jens and Uwe W Heemann},
  journal={Kidney international},
  year={2002},
  volume={61 2},
  pages={676-85}
}
BACKGROUND Initial insults to kidney allografts, characterized by infiltration of mononuclear inflammatory cells, contribute to chronic allograft nephropathy. Chemokines such as RANTES (regulated upon activation, normal T cell expressed) are thought to be responsible for the recruitment and activation of infiltrating cells. The present study investigated whether early application of Met-RANTES, a chemokine receptor antagonist that blocks the effects of RANTES, can protect renal allografts from… CONTINUE READING

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