Early antipyretic exposure does not increase mortality in patients with gram-negative severe sepsis: a retrospective cohort study.

@article{Mohr2012EarlyAE,
  title={Early antipyretic exposure does not increase mortality in patients with gram-negative severe sepsis: a retrospective cohort study.},
  author={Nicholas M Mohr and Lee P. Skrupky and Brian M. Fuller and Hawnwan Philip Moy and Robert L Alunday and Michael J. Wallendorf and Scott T. Micek and Richard E Fagley},
  journal={Internal and emergency medicine},
  year={2012},
  volume={7 5},
  pages={463-70}
}
Existing data suggest that antipyretic medications may have deleterious effects on immune function and may increase mortality in human infection. This study was designed to evaluate the impact of antipyretic therapy on 28-day in-hospital mortality when administered early in the course of gram-negative severe sepsis or septic shock. This study was a single-center retrospective cohort study at a 1,111-bed academic medical center of all febrile patients with gram-negative bacteremia hospitalized… CONTINUE READING

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