Early antigen-specific response by naive CD8 T cells is not altered with aging.

@article{Li2002EarlyAR,
  title={Early antigen-specific response by naive CD8 T cells is not altered with aging.},
  author={Shaokang P. Li and Zeling Cai and Weixing Shi and Anders P. Brunmark and Michael Jackson and P. L. Linton},
  journal={Journal of immunology},
  year={2002},
  volume={168 12},
  pages={6120-7}
}
Both a dramatic decline in CD8 responses and a switch to memory T cell predominance occur with aging. The extent to which the loss of responsiveness is the consequence of the accumulation of more differentiated vs intrinsically defective T cells (or both) has been unclear. Using similar conditions of Ag stimulation, we have examined the responses generated by CD8(+) cells isolated from aged TCR transgenic mice. We found that the naive transgene(+) CD8(+) cells from aged 2C mice expressed… CONTINUE READING

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