Early antagonism of cerebral high mobility group box-1 protein is benefit for sepsis induced brain injury

Abstract

Sepsis induced brain injury acts as an acute complication and accounts for deterioration and high mortality rate of septic condition. HMGB1 is a late inflammatory mediator that plays a critical role in brain dysfunction and diseases. However, the role of HMGB1 in sepsis induced brain dysfunction remains intricate. The current study investigated the effect… (More)
DOI: 10.18632/oncotarget.21502

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