Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus.

@article{Baskin2009EarlyAS,
  title={Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus.},
  author={Carole R. Baskin and Helle Bielefeldt-Ohmann and Terrence M. Tumpey and Patrick J. Sabourin and James P. Long and Adolfo Garc{\'i}a-Sastre and Airn-E Tolnay and Randy A Albrecht and John A. Pyles and Pam H Olson and Lauri D. Aicher and Elizabeth R Rosenzweig and Kaja Murali-Krishna and Edward A. Clark and Mark S. Kotur and Jamie L. Fornek and Sean C. Proll and Robert E Palermo and Carol Sabourin and Michael G. Katze},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 9},
  pages={
          3455-60
        }
}
The mechanisms responsible for the virulence of the highly pathogenic avian influenza (HPAI) and of the 1918 pandemic influenza virus in humans remain poorly understood. To identify crucial components of the early host response during these infections by using both conventional and functional genomics tools, we studied 34 cynomolgus macaques (Macaca fascicularis) to compare a 2004 human H5N1 Vietnam isolate with 2 reassortant viruses possessing the 1918 hemagglutinin (HA) and neuraminidase (NA… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 198 CITATIONS

FILTER CITATIONS BY YEAR

2009
2019

CITATION STATISTICS

  • 17 Highly Influenced Citations

  • Averaged 14 Citations per year over the last 3 years

References

Publications referenced by this paper.
SHOWING 1-10 OF 51 REFERENCES

Gene expression analysis of host innate immune responses during lethal H5N1 infection in ferrets

  • CM Cameron
  • J Virol 82:11308–11317
  • 2008
2 Excerpts

Similar Papers

Loading similar papers…