Early and progressive helper T-cell dysfunction in feline leukemia virus-induced immunodeficiency.

@article{Diehl1992EarlyAP,
  title={Early and progressive helper T-cell dysfunction in feline leukemia virus-induced immunodeficiency.},
  author={Lauri J. Diehl and Edward A. Hoover},
  journal={Journal of acquired immune deficiency syndromes},
  year={1992},
  volume={5 12},
  pages={1188-94}
}
Cats infected with the highly pathogenic feline leukemia virus isolate FeLV-FAIDS develop an immunodeficiency syndrome characterized by progressive loss of CD4+ T cells and eventual pan-lymphocyte depletion. Prior to the decline in circulating CD4+ cells, infected cats are unable to mount primary antibody responses to T-dependent antigens. We investigated whether the altered ability of helper T cells to produce cytokines necessary for B cell growth and differentiation might be a primary event… CONTINUE READING

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