Early and multiple origins of metastatic lineages within primary tumors.

  title={Early and multiple origins of metastatic lineages within primary tumors.},
  author={Jeffrey P Townsend and Bixiao Zhao and Yalai Bai and Atila Iamarino and Stephen G. Gaffney and Joseph Schlessinger and Richard P. Lifton and David L. Rimm and Jeffrey P. Townsend},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={113 8},
Many aspects of the evolutionary process of tumorigenesis that are fundamental to cancer biology and targeted treatment have been challenging to reveal, such as the divergence times and genetic clonality of metastatic lineages. To address these challenges, we performed tumor phylogenetics using molecular evolutionary models, reconstructed ancestral states of somatic mutations, and inferred cancer chronograms to yield three conclusions. First, in contrast to a linear model of cancer progression… CONTINUE READING
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