Early and longer term effects of gastric bypass surgery on tissue-specific insulin sensitivity and beta cell function in morbidly obese patients with and without type 2 diabetes

@article{Camastra2011EarlyAL,
  title={Early and longer term effects of gastric bypass surgery on tissue-specific insulin sensitivity and beta cell function in morbidly obese patients with and without type 2 diabetes},
  author={Stefania Camastra and Amalia Gastaldelli and Andrea Mari and Sandra Bonuccelli and Giovanna Scartabelli and Silvia Frascerra and Simona Baldi and Monica Nannipieri and Eleni Rebelos and Marco Anselmino and Elza O Muscelli and Ele Ferrannini},
  journal={Diabetologia},
  year={2011},
  volume={54},
  pages={2093-2102}
}
Bariatric surgery consistently induces remission of type 2 diabetes. We tested whether there are diabetes-specific mechanisms in addition to weight loss. We studied 25 morbidly obese patients (BMI 51.7 ± 1.5 kg/m2 [mean ± SEM]), 13 with non-insulin-treated type 2 diabetes (HbA1c 7.1 ± 0.5% [54 ± 5 mmol/mol]), before and at 2 weeks and 1 year after Roux-en-Y gastric bypass (RYGB). Lean (n = 8, BMI 23.0 ± 0.5 kg/m2) and obese (n = 14) volunteers who were BMI-matched (36.0 ± 1.2) to RYGB patients… CONTINUE READING
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